Publications & Conferences

Publications by year since 2006

Peer-reviewed publications

  1. MLD Rayner, S Laranjeira Gomes, RJ Shipley, J Healy, JB Phillips, 2017. An Engineered Neural Tissue Co-Culture Model to Screen Drugs for Nerve Regeneration. Submitted.
  2. P Muangsanit, RJ Shipley, JB Phillips, 2017. Vascularisation Strategies for Peripheral Nerve Tissue Engineering. Submitted.
  3. A d’Esposito*, P Sweeney*, M Ali, M Saleh, R Ramasawmy, TA Roberts, A Desjardins, MF Lythgoe, RB Medley, RJ Shipley*, S Walker-Samuel*, 2017. Combining Optical Imaging of Cleared Tissue with Mathematical Modelling to Predict Drug Delivery and Therapeutic Response. Submitted
    * joint first/ joint last
  4. PW Sweeney, S Walker-Samuel, RJ Shipley, 2017. Insights into Cerebral Haemodynamics and Oxygenation Utilising In Vivo Mural Cell Imaging and Mathematical Modelling. Submitted
  5. JC Madden, S Webb, SJ Enoch, HE Colley, C Murdoch, RJ Shipley, P Sharma, C Yang MTD Cronin, 2017. In Silico Prediction of Skin Metabolism and its Implication in Toxicity Assessment. Computational Toxicology (3): doi: 10.1016/j.comtom.2017.07.001
  6. LAC Chapman, HM Byrne, JP Whiteley, SL Waters, RJ Shipley, 2017. Mathematical Modelling of Cell Layer Growth in a Hollow Fibre Bioreactor. Journal of Theoretical Biology (418): doi: 10.1016/j.jtbi.2017.01.016
  7. I Sorrell, RJ Shipley, S Regan, I Gardner, M Ellis, J Ward, D Williams, S Webb, 2016. Mathematical Modelling of a Hollow Fibre Bioreactor for Systemic Toxicity Testing. Accepted for publication in PLoS One
  8. R Coy, OR Evans JB Phillips, RJ Shipley, 2016. An Integrated Theoretical-Experimental Approach to Accelerate Translational Tissue Engineering. Tissue Engineering and Regenerative Medicine. doi: 10.1002/term.2346
  9. V Vavourakis, PA Wijeratne*, RJ Shipley*, T Stylianopoulos, M Loizidou, DJ Hawkes, 2017. A Validated Multiscale In-Silico Model for Mechano-Sensitive Tumour Angiogenesis and Growth. PLoS Computational Biology: doi: 10.1371/journal.pcbi.1005259
    *authors contributed equally to the work
  10. CF Graham, S Windsor, A Adjuk, P Sweeney, I Tagbo, T Trinh, D Kalsi, M Zernicka-Goetz, RJ Shipley K Swann, A Thomas, 2016. Zygote Dynamics. Submitted to Developmental Dynamics
  11. MP Storm, I Sorrell, R Shipley, S Regan, J Sathish, S Webb, MJ Ellis, 2016. Hollow Fiber Bioreactors for In Vivo-Like Mammalian Tissue Culture. Journal of Visualized Experiments: JoVE (111): doi: 10.3791/53431.
  12. NC Pearson, JM Oliver, RJ Shipley, SL Waters, 2016. A Multiphase Model for Chemically- and Mechanically-Induced Cell Differentiation in a Hollow Fibre Membrane Bioreactor: Minimising Growth Factor Consumption. Biomechanics and Modeling in Mechanobiology, 15(3): 683-700. doi:10.1007/s10237-015-0717-6
  13. K-A Kwon, RJ Shipley, M Edirisinghe, SM Best, RE Cameron, C Poitelea, GE Rose, D Ezra, 2016. The Mechanics of Brow-Suspension Ptosis Repair: A Comparative Study of Fox Pentagon and Crawford Triangle Techniques. Journal of Ophthalmic Plastic and Reconstructive Surgery. doi: 10.1097/IOP.0000000000000621
  14. AF Smith, TW Secomb, AR Pries, NP Smith & RJ Shipley, 2015. Structure-Based Algorithms for Microvessel Classification. Microcirculation, 22(2):99-108 doi: 10.1111/micc.12181
  15. K-A Kwon, RJ Shipley, M Edirisinghe, AW Rayment, SM Best, RE Cameron, T Salam, GE Rose, D Ezra, 2015. Stress-relaxation and fatigue behaviour of synthetic brow-suspension materials. Journal of the Mechanical Behavior of Biomedical Materials, 42: 116-128. doi:10.1016/j.jmbbm.2014.11.004
  16. NC Pearson, JM Oliver, SL Waters & RJ Shipley, 2015. Multiphase Modelling of the Effect of Fluid Shear Stress on Cell Yield and Distribution in a Hollow Fibre Membrane Bioreactor. Biomechanics and Modeling in Mechanobiology. 14(2):387-402 doi:10.1007/s10237-014-0611-7
  17. NC Pearson, RJ Shipley, SL Waters & JM Oliver, 2014. Dispersion-Enhanced Solute Transport in a Cell-Seeded Hollow Fibre Membrane Bioreactor. Journal of Engineering Mathematics. 99(1): 29-63 doi:10.1007/s10665-015-9819-5
  18. LAC Chapman, RJ Shipley, JP Whiteley, MJ Ellis, HM Byrne & SL Waters, 2014. Optimising Cell Aggregate Expansion in a Perfused Hollow Fibre Bioreactor via Mathematical Modelling. PLoS One, 9(8), e105813. doi:10.1371/journal/pone.0105813
  19. A Ardakani, U Cheema, RA Brown, RJ Shipley 2014. Quantifying the Correlation between Spatially Defined Oxygen Gradients and Cell Fate in an Engineered 3D Culture Model. J Roy Soc Int. 11(98): 20140501. doi.org/10.1098/rsif.2014.0501
  20. AF Smith, RJ Shipley, J Lee, GB Sands, IJ LeGrice, NP Smith, 2014. Transmural Variation and Anisotropy of Microvascular Flow Conductivity in the Rat Myocardium. Annals of Biomedical Engineering, 42(9): 1966-77. doi: 10.1007/s10439-014-1028-2
  21. CJ Kelly, K Hussein, E Fokas, P Kannan, RJ Shipley, TM Ashton, M Stratford, N Pearson & RJ Muschel, 2014. Regulation of O2 Consumption by the P13K and mTOR Pathways Contributes to Tumor Hypoxia, 2014. Radiotherapy and Oncology, 111(1): 72-80. doi:10.1016/j.radonc.2014.02.007
  22. J-A Kwon, RJ Shipley, M Edirisinghe, D Ezra, G Rose, AW Rayment, SM Best & RE Cameron, 2014. Microstructure and Mechanical Properties of Synthetic Brow-Suspension Materials. Mater. Sci. Eng. C – Materials for Biological Applications, 1(35): 220-30. doi: 10.1016/j.msec.2013.10.031
  23. R Penta, D Ambrosi & RJ Shipley, 2014. Homogenized Governing Equations for Poroelastic Growing Media. Quarterly Journal of Mechanics and Applied Mathematics 67(1): 69-91 doi: 10.1093/qjmam/hbt024
  24. I Sorrel, RJ Shipley, V Hearnden, HE Colley, MH Thornhill, C Murdoch & SD Webb, 2014. Combined Mathematical Modelling and Experimentation to Predict Polymersome Uptake by Oral Cancer Cells. Nanomedicine: Nanotechnology, Biology, and Medicine 10(2): 339-48 doi.org/10.1016/j.nano.2013.08.013
  25. Y Davit et al., 2013. Homogenization Via Formal Multiscale Asymptotics and Volume Averaging: How do the Two Techniques Compare? Advances in Water Resources 62: 178-206. doi.org/10.1016/j.advances.2013.09.006
  26. NC Pearson, RJ Shipley, SL Waters & JM Oliver, 2013. Multiphase Modelling of the Influence of Fluid Flow and Chemical Concentration on Tissue Growth in Hollow Fibre Membrane Bioreactors. Mathematical Medicine & Biology doi:10.1093/imammb/dqt015
  27. J-A Kwon, RJ Shipley, D Ezra, G Rose, SM Best, RE Cameron, M Edirisinghe, 2013. High-Speed Camera Characterisation of Voluntary Eye Blinking Kinematics. Journal of the Royal Society Interface, 10(85):20130227. doi: 10.1098/rsif.2013.0227
  28. IM Griffiths, PD Howell & RJ Shipley, 2013. Control and Optimization of Solute Transport in a Porous Tube. Physics of Fluids, 25:033101. doi: 10.1063/1.4795545
  29. DP Williams, RJ Shipley, MJ Ellis, S Webb, J Ward, I Gardner & S Creton, 2013. Novel In Vitro & Mathematical Models for the Prediction of Chemical Toxicity. Toxicology Research, 2(1):40-59 doi: 10.1039/C2TX20031G
  30. RJ Shipley & SL Waters, 2012. Fluid and Mass Transport Modelling to Drive the Design of Cell-Packed Hollow Fibre Bioreactors for Tissue Engineering Applications. Mathematical Medicine & Biology, 29: 329-359 doi: 10.1093/imammb/dqr025
  31. RJ Shipley, SL Waters & MJ Ellis, 2011. Fluid and Mass Transport Modelling to Drive the Design of Cell-Packed Hollow Fibre Bioreactors. European Cells and Materials, 22 (Supplement 3):72
  32. SL Waters, J Alastruey, DA Beard, PHM Bovendeerd, PF Davies, G Jayaraman, OE Jensen, J Lee, KH Parker, AS Popel, TW Secomb, SJ Sherwin, RJ Shipley, NP Smith & FN Vosse, 2010. Theoretical Models for Coronary Vascular Biomechanics: Progress & Challenges. Progress in Biophysics and Molecular Biology, 104:49–76. doi: 10.1016/j.pbiomolbio.2010.10.001
  33. RJ Shipley, SL Waters & MJ Ellis, 2010. Definition and Validation of Operating Equations for Poly(vinyl alcohol)-Poly(lactide-co-glycolide) Microfiltration Membrane-Scaffold Bioreactors. Biotechnology and Bioengineering, 107(2):382–392. doi: 10.1002/bit.22815
  34. RJ Shipley & SJ Chapman, 2010. Multiscale Modelling of Fluid and Drug Transport in Vascular Tumours. Bulletin of Mathematical Biology, 72(6):1464–1491. doi: 10.1007/s11538-010-9504-9
  35. RJ Shipley, GW Jones, RJ Dyson, BG Sengers, CL Bailey, CP Please & J Malda, 2009. Design Criteria for a Printed Tissue Engineering Construct: A Mathematical Homogenization Approach, Journal of Theoretical Biology, 259(2): 489–502. doi: 10.1016/j.jtbi.2009.03.037
  36. RJ Shipley, MB Bonsall, DJ Allwright & CF Graham, 2009. Theoretical Exploration of Blastocyst Morphogenesis, International Journal of Developmental Biology, 53(4):447–457. doi: 10.1387/ijdb.082587rs
  37. M Soleimani, RJ Shipley, NP Smith & CN Mitchell, 2009. Medical Imaging and Physiological Modelling: Linking Physics and Biology, BioMedical Engineering OnLine, 8(1):1–3. doi: 10.1186/1475-925X-8-1
  38. SJ Chapman, RJ Shipley & R Jawad, 2008. Multiscale Modeling of Fluid Transport in Tumors, Bulletin of Mathematical Biology, 70(8):2334–57. doi: 10.1007/s11538-008-9349-7
  39. R Carter & MB Giles, 2007. Sharp Error Estimates for Discretizations of the 1D Convection/ Diffusion Equation with Dirac Initial Data. Institute for Mathematics and its Applications Journal of Numerical Analysis, 27(2): 406-425
  40. MB Giles & R Carter, Summer 2006. Convergence Analysis of Crank-Nicolson and Rannacher Time Marching. Journal of Computational Finance, 9(4):89

Conference Items

  1. Coy, R., Kennedy, G., Kayal, C., O’Rourke, C., Kingham, P., Phillips, J., & Shipley, R. J. (2016). A mathematical model informed by in vitro experiments to advance engineered nerve repair construct design. In European Cells and Materials Vol. 32 (pp. 36). University College London: European Cells & Materials Ltd.
  2. Kayal, C., Shipley, R. J., & Phillips, J. (2016). Effect of collagen gel concentration gradients on neurite elongation. In European Cells and Materials Vol. 32 (pp. 83). University College London: European Cells & Materials Ltd.
  3. Smith, S., Colley, H., Sharma, P., Shipley, R. J., Madden, J., Cronin, M., Webb, S., Murdoch, C. (2016). Functional expression of xenobiotic metabolizing enzymes in human skin and tissue engineered skin equivalents. In European Cells and Materials Vol. 32 (pp. 88). University College London: European Cells & Materials Ltd.
  4. Kennedy, G., Coy, R., Kayal, C., O’Rourke, C., Kingham, P., Shipley, R. J., & Phillips, J. (2016). In vitro experiments to inform cell seeding strategies and parameterize a mathematical model for peripheral nerve repair. In European Cells and Materials Vol. 32 (pp. 21). University College London: European Cells & Materials Ltd.
  5. Nweze, M., Baker, T., Limb, A., & Shipley, R. J. (2016). Mathematical modelling as a tool to inform the design of spray systems for cell-based therapies. In European Cells and Materials Vol. 32 (pp. 126). University College London, London: European Cells & Materials Ltd.
  6. Burova, I., Wall, I., & Shipley, R. J. (2016). Mathematical modelling of oxygen, glucose and lactic acid reaction kinetics for osteoblasts and mesenchymal stem cells. In European Cells and Materials Vol. 32 (pp. 137). University College London: European Cells & Materials Ltd.
  7. Coy, R., Kennedy, G., Kayal, C., O’Rourke, C., Kingham, P., Phillips, J., & Shipley, R. J. (2016). A joint theoretical-experimental approach to investigate the effects of low oxygen environments upon therapeutic cell viability and VEGF production. In European Cells and Materials Vol. 31 (pp. 174). Sweden: European Cells & Materials Ltd.
  8. Shipley, R. J. (2016). A mathematical model with the capacity to direct and accelerate the design of cellular peripheral nerve repair conduits. In European Cells and Materials Vol. 31 (pp. 159). Sweden: European Cells & Materials Ltd.
  9. Webb, S., Sorrell, I., Shipley, R. J., Regan, S., Gardner, I., Storm, M., Williams, D. (2016). Mathematical modelling of a liver hollow fibre bioreactor. In European Cells and Materials Vol. 32 (pp. 28). University College London: European Cells & Materials Ltd.
  10. Shipley, R. J., Webb, S., Madden, J., Smith, S., Sharma, P., Cronin, M., Colley, H., Murdoch, C. (2016). Mathematical modelling predicts the spatial distribution of metabolism in skin. In European Cells and Materials Vol. 32 (pp. 96). University College London: European Cells & Materials Ltd.
  11. Wijeratne, P., Vavourakis, V., Hipwell, J. H., Shipley, R., Stylianopoulos, T., Evans, A., Hawkes, D. J. (2016). Multiscale biphasic modelling of tumour growth: the effect of collagen micromechanics on drug delivery. In European Congress on Computational Methods in Applied Sciences and Engineering – ECCOMAS 2016. Crete Island, Greece.
  12. Vavourakis, V., Wijeratne, P., Shipley, R., Stylianopoulos, T., & Hawkes, D. J. (2016). The mechanical underpinning of tumour-induced angiogenesis and growth. In 24th Conference on Computational Mechanics. Cardiff, UK.
  13. Evans, O., Phillips, J., & Shipley, R. J. (2014). A mathematical framework for nerve regeneration in implantable conduits. In European Cells and Materials Vol. 28 (pp. 116). Newcastle: European Cells & Materials Ltd.
  14. Hamy, V., Modat, M., Dikaios, N., Cleary, J., Punwani, S., Shipley, R., Ourselin, S., Atkinson, D., Melbourne, A. (2014). Multi-modal pharmokinetic modelling for DCE-MRI: using diffusion weighted imaging to constrain the local arterial input function (2014). In SPIE Medical Imaging (pp. 9034-26). San Diego, California, United States
  15. Shipley, R. J., Ardakani, A., Stamati, K., Cheema, U., & Brown, R. (2013). Control of cell fate and oxygen gradients in collagen constructs for tissue engineering applications. In Tissue and Cell Engineering Society Vol. 26 (pp. 33). Cardiff: European Cells & Materials Ltd.
  16. Chapman, L. A. C., Shipley, R. J., Ellis, M. J., Whiteley, J. P., Byrne, H. M., & Waters, S. L. (2013). Influence of cell seeding and fluid flow on cell aggregate growth in hollow fibre bioreactors. In European Cells and Materials Vol. 26 (pp. 2). Cardiff: European Cells & Materials Ltd.
  17. Shipley, R. J., Ellis, M. J., & Waters, S. L. (2013). Fluid and mass transport modelling to drive the design of cell-packed hollow fibre bioreactors. In Tissue Engineering and Regenerative Medicine International Society – EU Meeting, 17-20 June 2013, Istanbul, Turkey
  18. Pearson, N., Shipley, R. J., Waters, S., & Oliver, J. (2013). Multiphase modelling of tissue growth in a hollow fibre membrane bioreactor. In Tissue Engineering and Regenerative Medicine International Society – EU Meeting, 17-20 June 2013, Istanbul, Turkey
  19. Shipley, R. J., Ardakani, A., & Brown, R. (2013). Controlling spatial heterogeneity in cell density in collagen constructs. In Tissue Engineering and Regenerative Medicine International Society – EU Meeting, 17-20 June 2013, Istanbul, Turkey
  20. Shipley, R. J., Bohun, S., Ledder, G., Moulton, D., Ward, J., & Moldovan, N. (2013). Modelling the magnetic force-controlled colonisation of fibrous scaffolds by stem Cells. In Tissue Engineering and Regenerative Medicine International Society – EU Meeting, 17-20 June 2013, Istanbul, Turkey
  21. Griffiths, I., & Shipley, R. J. (2012). A mathematical model for the transport of a solute through a porous-walled tube. In American Physical Society Vol. 57. Bulletin of the American Physical Society.
  22. Chapman, L. A. C., Waters, S. L., Shipley, R. J., Byrne, H. M., Whiteley, J. P., & Ellis, M. J. (2012). Modelling fluid and nutrient transport to determine the influence of cell seeding on the growth of cell aggregates on a permeable membrane. In European Cells and Materials Vol. 23 (pp. 99). Liverpool: European Cells & Materials Ltd.
  23. Ardakani, A., Shipley, R. J., Stamati, K., Cheema, U., & Brown, R. A. (2012). Quantifying spatial and temporal variation in cell function in collagen constructs for tissue engineering applications. In European Cells and Materials Vol. 23 (pp. 58). Liverpool: European Cells & Materials Ltd.
  24. Ardakani, A., Stamati, K., Brown, R. A., Cheema, U., & Shipley, R. J. (2012). Quantifying spatial and temporal variation in cell function in collagen constructs for tissue engineering applications. In Tissue Engineering and Regenerative Medicine International Society – World Congress 2012, 5-8 September 2012, Vienna, Austria
  25. Shipley, R. J., Ardakani, A., Cheema, U., & Brown, R. (2012). Quantifying spatial variations in cell density in collagen scaffolds: a combined theoretical-experimental approach. In Tissue Engineering and Regenerative Medicine International Society – World Congress 2012, 5-8 September 2012, Vienna, Austria
  26. Shipley, R. J., Waters, S. L., & Ellis, M. J. (2011). Fluid and mass transport modelling to drive the design of cell-packed hollow fibre bioreactors. In European Cells and Materials Vol. 22 (pp. 72). Leeds: European Cells & Materials Ltd.
  27. Shipley, R. J., & Ellis, M. J. (2009). Characterisation of fluid and protein transport properties in hollow fibre membrane scaffolds. In European Cells and Materials Vol. 18 (pp. 40). Glasgow: European Cells & Materials Ltd.
  28. Shipley, R. J., Ellis, M. J., & Waters, S. L. (2009). Combining mathematical modelling with experimental data to characterize fluid and protein transport properties in hollow fibre scaffolds. In Interdisciplinary Transport Phenomena Conference VI. Italy.
  29. Shipley, R. J., Webb, S. D., Waters, S. L., McDougall, S. R., & Roberts, F. (2009). Mathematical modelling of nanoparticle delivery to vascular tumours. In 2nd Micro and Nano Flows Conference. Brunel.
  30. Shipley, R. J., & Ellis, M. J. (2009). PLGA hollow fibre membrane scaffolds and serum protein interactions. In European Cells and Materials Vol. 18 (pp. 62). Glasgow: European Cells & Materials Ltd